All findings
15 results read out of 6 full texts in this archive. Each was extracted by a language model and kept only if its quote appears on the cited page. Not yet reviewed by a person: open the quote and the source before relying on one.
Observational studies (1 from 1 source)
2011 Профилактика преждевременного старения работающих в неблагоприятных условиях профессиональной деятельности · railway workers vs control group CyberLeninka
- Before pinealon use, railway workers with high anxiety showed higher heart rate, blood pressure, and KEK compared to a control group, indicating increased cardiovascular strain, with the effect more pronounced in the older age group.
Quote, p. 7
повышение артериального давления (АД) и КЭК указывает на увеличение напряженности в функционировании сердечно-сосудистой системы
- Before pinealon use, railway workers with high anxiety showed higher heart rate, blood pressure, and KEK compared to a control group, indicating increased cardiovascular strain, with the effect more pronounced in the older age group.
Animal experiments (8 from 3 sources)
2019 Влияние трипептида Пинеалона на реабилитацию когнитивных функций в процессе старения на примере макак-резусов… · n = 1 · Female rhesus macaque (Macaca mulatta) CyberLeninka
- In a female rhesus macaque, motor reaction time during learning decreased from 1.668 s to 1.387 s after Pinealon administration (p < 0.005).
Quote, p. 6
время моторной реакции самки при обучении до введения Пинеалона составляло 1,668 сек, а после него сократилось до 1,387 сек (p < 0,005)
- The correlation coefficient (R²) between the number of concentration reactions preceding stimulus choice and task success was 0.1 before Pinealon and increased to 0.56 after the Pinealon course once macaques reached the 75% correct-response threshold.
Quote, p. 7
коэффициент корреляции между этим показателями достигет значимых величины и равнялся 0,56
- A direct correlation was found between the increasing number of concentration reactions prior to choice making and the success of the task in macaques given Pinealon.
Quote, p. 11
Also, a direct correlation was found between the increasing number of concentration reactions prior to the choice making and the success of the task.
- In a female rhesus macaque, motor reaction time during learning decreased from 1.668 s to 1.387 s after Pinealon administration (p < 0.005).
2015 Исследование актопротекторных свойств трипептида пинеалона · rats CyberLeninka
- Chronic pinealon administration in rats caused a more pronounced decrease in creatine kinase activity (by 28.5%), a 15.6% reduction in magnesium ion concentration, and a 21.7% decrease in LDH activity relative to the confidence interval.
Quote, p. 5
падение активности КрК было более выраженным (на 28,5 %) и сопровождалось уменьшением концентрации ионов магния на 15,6 %. Снижение активности ЛДГ составило 21,7 %
- Lactate levels in rats receiving pinealon before physical load were 2.50 ± 0.29 mmol/L and after load 6.87 ± 1.11 mmol/L, with a 2–4 fold increase indicating a substantial anaerobic component of energy supply.
Quote, p. 5
Изменение уровня лактатов составило: до нагрузки 2,50 ± 0,29, после нагрузки 6,87 ± 1,11 ммоль/л
- Hematological changes in pinealon-treated rats were adaptive rather than pathological, correlating with duration of daily physical loads, with more pronounced changes accompanying the longest running time to exhaustion.
Quote, p. 6
Введение пинеалона оказывало наиболее выраженные изменения гематологических показателей на фоне максимальной продолжительности «бега до отказа».
- Chronic pinealon administration in rats caused a more pronounced decrease in creatine kinase activity (by 28.5%), a 15.6% reduction in magnesium ion concentration, and a 21.7% decrease in LDH activity relative to the confidence interval.
2021 Влияние пептидных биорегуляторов на свободнорадикальные процессы и уровень экспрессии генов sod1, gpx4 и gsr… · rats in diabetes model CyberLeninka
- The study reports no high correlation between changes in activity of all studied antioxidant enzymes and their gene expression across different experimental models.
Quote, p. 4
Полученные результаты указывают на отсутствие высоких корреляционных связей между изменением активности всех исследованных в работе антиоксидантных ферментов и экспрессией их генов в разных экспериментальных моделях.
- The study reports no high correlation between changes in activity of all studied antioxidant enzymes and their gene expression across different experimental models.
Cell and tissue studies (6 from 3 sources)
2024 Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes · human dermal fibroblasts from elderly donors, transdifferentiated into induced cortical neurons PDF
- Pinealon (KED), EDR, and AEDG peptides all promoted arborization of the dendritic tree in fibroblast-derived induced neurons, increasing both the number of primary processes and the total length of dendrites.
Quote, p. 1
All peptides promote the arborization of the dendritic tree, increasing both the number of primary processes and the total length of dendrites.
- Pinealon (KED), EDR, and AEDG tripeptides had no effect on the activity of mitochondria and lysosomes or on the level of p16 protein in fibroblast-derived induced neurons.
Quote, p. 1
Tripeptides have no effect on the activity of mitochondria and lysosomes and the level of p16 protein in induced neurons.
- The authors proposed a new in vitro cellular model of human neuronal aging based on the transdifferentiation of aged dermal fibroblasts from elderly donors into induced cortical neurons.
Quote, p. 1
We used a new in vitro cellular model of human neuronal aging based on the transdifferentiation of aged dermal fibroblasts from elderly donors into induced cortical neurons.
- Pinealon (KED), EDR, and AEDG peptides all promoted arborization of the dendritic tree in fibroblast-derived induced neurons, increasing both the number of primary processes and the total length of dendrites.
2018 Применение пинеалона и кортексина для коррекции окислительного стресса в крови больных сахарным диабетом в… · whole blood with HbA1 6.2-12.0 CyberLeninka
- Introduction of pinealon in blood with HbA1 6.2-12.0 favored a considerable increase in extra-erythrocytic hemoglobin level alongside an increase in Sm (integral ROS generation index).
Quote, p. 6
Introduction of pinealon in blood with the level of HbA1 6.2-12.0 favoured a considerable increase of extra-erythrocytic hemoglobin level against the background of Sm increase
- Pinealon under hyperbaric oxygenation modeling predominantly increases peroxidase activity (likely via its pro-oxidant component), while extra-erythrocytic hemoglobin level does not increase significantly compared to cortexin models.
Quote, p. 6
With the introduction of the pinealon into the blood and the modeling of hyperbaric oxygenation, the total peroxidase activity increases, but the level of extraerythrocyte hemoglobin does not increase as much as in models with the administration of cortexin
- Introduction of pinealon in blood with HbA1 6.2-12.0 favored a considerable increase in extra-erythrocytic hemoglobin level alongside an increase in Sm (integral ROS generation index).
2015 Исследование актопротекторных свойств трипептида пинеалона · rat cerebellar granular cells, human and rat erythrocytes CyberLeninka
- In vitro studies on isolated rat cerebellar granular cells and on human and rat erythrocytes showed that Pinealon controls accumulation of reactive oxygen species.
Quote, p. 1
Показана способность пинеалона контролировать накопление активных форм кислорода.
- In vitro studies on isolated rat cerebellar granular cells and on human and rat erythrocytes showed that Pinealon controls accumulation of reactive oxygen species.