All findings
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Animal experiments (3 from 1 source)
2005 Особенности фармакокинетики распределения актопротекторов бромантана и хлодантана у крыс · n = 150 · rats CyberLeninka
- For chlodantane, two categories of rat tissues were distinguished by exchange rate with plasma: fast-equilibrating (brain, liver, spleen, testes, kidneys, lungs, skeletal muscle) and slow-equilibrating (adipose tissue).
Quote, p. 3
Также существуют два вида тканей, характеризующихся различными скоростями обмена хлодантана с плазмой крови: первая — ткани, быстро приходящие в равновесие с плазмой крови (мозг, печень, селезенка, семенники, почки легкие, скелетные мышцы)
- Chlodantane displayed very high apparent bioavailability values in skeletal muscle (5945.5%), adipose tissue (3780%) and testes (437%), with plasma F of 88%; Cmax reached 11,383.5 ng/g in skeletal muscle and t1/2 in skeletal muscle was 426.8 h.
Quote, p. 4
Скелетные мышцы 5945,5 0,0016 426,8 1,0 11 383,5
- Chlodantane showed long terminal elimination half-lives in rats (plasma 125.53 h, lungs 178.8 h, testes 89.9 h) with plasma Cmax of 594.7 ng/g reached at 1 h.
Quote, p. 4
Плазма крови (по сравнению с в/в введением) 88 0,0055 125,53 1,0 594,7
- For chlodantane, two categories of rat tissues were distinguished by exchange rate with plasma: fast-equilibrating (brain, liver, spleen, testes, kidneys, lungs, skeletal muscle) and slow-equilibrating (adipose tissue).