A synthetic liver-framed tetrapeptide (KEDG) from the Khavinson line with a thin dedicated product trail and broader short-peptide adjacency.
Bioregulator · Khavinson school · Lys-Glu-Asp-Gly (KEDG)
C18H31N5O9 · KEDG
identity
sequence
Lys · Glu · Asp · Gly
codeKEDG|linebioregulator|schoolKhavinson
Archive sequence label. Residue order as used in this dossier. No clinical structure claim.
Key takeaways
Livagen is the synthetic tetrapeptide Lys-Glu-Asp-Gly (KEDG), framed as liver-tissue-specific in the Khavinson bioregulator line. It is not a bovine-liver extract.
Dedicated Livagen product monographs are scarce in our CyberLeninka audit. Mapped texture is mostly adjacent hepatocyte, immune and ophthalmology bioregulator papers plus a few PubMed genomic / digestive-enzyme titles.
This page records a research gap honestly. Adjacency is not product proof.
What it is
Livagen is the synthetic tetrapeptide Lys-Glu-Asp-Gly from the Khavinson liver line. Defined sequence, not a mixed hepatic cytomedin.
School marketing language claims tissue-specific regeneration. Open dedicated pharmacology for the named product is thin in our map.
We keep it because KEDG appears in PubMed peptide-bioregulator titles and in the synthetic tetrapeptide family lists.
What the literature describes
Themed chapters drawn only from papers already mapped on this dossier. Archive map. No medical advice.
Named-peptide and digestive-enzyme frames
PubMed includes a title on peptide Livagen effects on digestive enzyme activity in gastrointestinal and non-digestive organs across ages, and a 2020 title on polypeptide liver complex and tetrapeptide KEDA in age-related pathology. Those are the clearest named-peptide hooks in the mapped set.
CyberLeninka adjacency includes circahourly protein metabolism rhythms in hepatocytes and general medicinal-peptide reviews. Ophthalmology bioregulator chips that merely co-occur in retrieval are secondary.
Several PubMed rows discuss peptide bioregulators with cobalt ions, fragile sites, hypertrophic cardiomyopathy relatives, and heterochromatin activation in aged lymphocytes. These are school neighbourhood papers that may name related peptides; they are not treated as Livagen clinical proof.
Dedicated product density is low. Digestive-enzyme and liver-complex PubMed titles are the firmest named hooks; much of the Russian chip cloud is adjacency.
Drosophila longevity peptide papers appear as school-wide texture.
Open limits
How much published work truly assays Livagen® versus neighbouring liver peptides?
Is KEDG present in any natural liver cytomedin fraction at meaningful levels?
Comparison with conventional hepatoprotectors is absent from our mapped set.
Russian full-text papers
Open-access Russian academic PDFs on CyberLeninka where we have them.
okolochasovye ritmy belkovogo metabolizma v gepatotsitah pri razlichnyhRussian full text
vliyanie peptidov na antioksidantnyy status i parametry krivyh vyzhivaniRussian full text
lekarstvennye peptidnye preparaty proshloe nastoyaschee buduscheeRussian full text
proliferotropnoe deystvie sochetaniy korotkih peptidov i kodiruemyh aminRussian full text
osoblivosti peptidergichnoyi regulyatsiyi imunokompetentnih klitinRussian full text
5 in corpus · off-focus immunology textbooks, calf colostrum, elderly ophthalmology service, AMD complex chips trimmed
Also on PubMed
2020[The influence of polypeptide liver complex and tetrapeptide KEDA on organism physiological function in norm and age-related pathology.].PubMed
2014[Effect of peptide bioregulator and cobalt ions on the activity of NORs and associations of acrocentric chromosomes in lymphocytes of patients with hypertrophic cardiomyopathy and their relatives].PubMed
2013[Functional regulation of genome with peptide bioregulators by hypertrophic cardiomyopathy (by patients and relatives)].PubMed
2008[The effect of heavy metal ions and peptide bioregulators on the expression of chromosome fragile sites in the individuals of different age groups and breast cancer patients].PubMed
2007Activation of pericentromeric and telomeric heterochromatin in cultured lymphocytes from old individuals. doi:10.1196/annals.1395.043PubMed
2005[Effect of peptide Livagen on activity of digestive enzymes in gastrointestinal tract and non-digestive organs in rats of different ages].PubMed
6 curated · ductal breast cancer genomic correction and atherosclerosis instability rows trimmed as weak compound hooks
Still open
Is there a dedicated Livagen® pharmacology monograph in print-only Russian sources?
How should KEDA versus KEDG spelling variants be unified in the map?
What liver-specific organotypic model would match prostatilen's prostate density?
Reviewed against the archive corpora on 2026-09-19. Source-grounded. No clinical claims. Archive / history / research only. No medical advice. No dosing, synthesis, sourcing, or health claims.