A synthetic cortex companion tetrapeptide (AEDP) from the Khavinson line, mapped through mollusk neuron biophysics and short-peptide immune titles.
Bioregulator · Khavinson school · Ala-Glu-Asp-Pro (AEDP)
C17H26N4O9 · AEDP
identity
sequence
Ala · Glu · Asp · Pro
codeAEDP|linebioregulator|schoolKhavinson
Archive sequence label. Residue order as used in this dossier. No clinical structure claim.
Key takeaways
Cortagen is the synthetic tetrapeptide Ala-Glu-Asp-Pro (AEDP), framed as a defined-sequence companion to the cortexin fraction.
Mapped mechanism texture includes intracellular microelectrode work in Planorbarius corneus pedal ganglia neurons (Shabanov-Vislohkov 2013) and a set of short-peptide chromatin / cytokine PubMed titles.
Published literature only under this exact name in our map. No Russian clinical registration claim is attached on this page.
What it is
Cortagen is the synthetic tetrapeptide Ala-Glu-Asp-Pro from the Khavinson cortical line. Defined sequence beside the mixed cortexin fraction.
School writing uses mollusk neuron biophysics as a classical assay for comparing cortagen and cortexin potency on membrane potential and spontaneous firing.
We keep it because AEDP gives a cleaner pharmacological handle than the fraction for the same tissue frame.
What the literature describes
Themed chapters drawn only from papers already mapped on this dossier. Archive map. No medical advice.
Mollusk neuron biophysics versus cortexin
Mapped synthesis describes cortagen 0.1-100 µM hyperpolarising Planorbarius corneus neurons by a few millivolts and reducing spontaneous impulse activity, with higher concentrations depolarising. School comparison language treats cortagen as more potent than cortexin in that assay. A CyberLeninka title pairs neuronoprotective action of cortexin and cortagen.
PubMed indexes a microarray title on cortagen effects on gene expression in mouse heart, plus short-peptide titles on lymphocyte chromatin, IL-2 mRNA in hypothalamic structures, and macrophage lymphocyte-activating factors during ageing.
Russian full text includes a molecular-dynamics title on Ala-Glu-Asp-Pro interaction with a model neuronal lipid membrane. A PubMed free-radical processes title covers bioactive tetrapeptides in the same school set.
The densest instrument trail is Shabanov-circle neuron electrophysiology plus short-peptide immune and chromatin titles on PubMed.
Drosophila antioxidant / survival peptide papers appear as school adjacency.
Open limits
Is AEDP present at meaningful concentration inside commercial cortexin fractions?
Mammalian in vivo pharmacology of pure AEDP is thinner than the mollusk assay suggests.
Which structural features separate cortagen's neuronal profile from sibling tetrapeptides remains open in our map.
Russian full-text papers
Open-access Russian academic PDFs on CyberLeninka where we have them.
mnogoletniy opyt nizkodozirovannoy peptidnoy neyroprotektsii v meditsineRussian full text
ispolzovanie regulyatornyh peptidov u patsientov nevrologicheskogo i stoRussian full text
neyronoprotektornoe deystvie korteksina i kortagenaRussian full text
vliyanie peptidov na antioksidantnyy status i parametry krivyh vyzhivaniRussian full text
issledovanie vzaimodeystviya tetrapeptida ala glu asp pro s modelnoy lipRussian full text
psihofarmakologicheskiy profil nootropopodobnyh peptidovRussian full text
farmakologiya lekarstvennyh preparatov peptidnoy strukturyRussian full text
dokazatelnost neyroprotektornyh effektov polipeptidnyh preparatov nereshRussian full text
8 in corpus · off-focus rows trimmed (orexin A currents, tobacco callus AEDL, nanostructure methods conference, Anichkov conference materials)
Also on PubMed
2007Effects of bioactive tetrapeptides on free-radical processes. doi:10.1007/s10517-007-0230-8PubMed
2006Production of lymphocyte-activating factors by mouse macrophages during aging and under the effect of short peptides. doi:10.1007/s10517-006-0366-yPubMed
2005Synthesis of IL-2 mRNA in cells of rat hypothalamic structures after injection of short peptides. doi:10.1007/s10517-005-0388-xPubMed
2004Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray.PubMed
2004Effects of short peptides on lymphocyte chromatin in senile subjects. doi:10.1023/b:bebm.0000024393.40560.05PubMed
2002In vitro effect of short peptides on expression of interleukin-2 gene in splenocytes. doi:10.1023/a:1020210615148PubMed
2002Effects of short peptides on thymocyte blast transformation and signal transduction along the sphingomyelin pathway. doi:10.1023/a:1019830308824PubMed
2002[Tissue-specific action of peptides in tissue culture of rats of various ages].PubMed
8 curated
Still open
Is AEDP a major active motif inside cortexin, or a synthetic stand-in?
Why does the defined tetrapeptide read as more potent than the fraction in the mollusk assay?
Which mammalian endpoints uniquely require pure AEDP, separate from cortexin?
Reviewed against the archive corpora on 2026-09-19. Source-grounded. No clinical claims. Archive / history / research only. No medical advice. No dosing, synthesis, sourcing, or health claims.