A synthetic bronchial tetrapeptide (AEDL) from the Khavinson short-peptide line, mapped for epithelial gene-regulation and obstructive-lung models.
Bioregulator · Khavinson school · Ala-Glu-Asp-Leu (AEDL)
C18H30N4O9 · AEDL
identity
sequence
Ala · Glu · Asp · Leu
codeAEDL|linebioregulator|schoolKhavinson
Archive sequence label. Residue order as used in this dossier. No clinical structure claim.
Key takeaways
Bronchogen is the synthetic tetrapeptide Ala-Glu-Asp-Leu (AEDL), drawn from a bronchial-epithelium polypeptide fraction in the Khavinson bioregulator line.
Mapped cell work clusters on renewal and differentiation genes in human bronchial epithelium, with related rat obstructive-lung pathology papers and a tobacco callus salinity series.
The densest trail is St. Petersburg short-peptide bronchial literature. This page is an archive map.
What it is
Bronchogen is the synthetic tetrapeptide Ala-Glu-Asp-Leu from the Khavinson bronchial line. Sequence characterised from a bronchial-epithelium polypeptide fraction, then made chemically.
It sits with the other synthetic tetrapeptides on this shelf (epitalon, cardiogen, cortagen and neighbours) as a tissue-framed short peptide. Mixed organ extracts sit elsewhere on this shelf.
We keep it in the wider archive because the bronchial gene-regulation series is one of the clearer molecular maps among the secondary bioregulators.
What the literature describes
Themed chapters drawn only from papers already mapped on this dossier. Archive map. No medical advice.
Bronchial epithelium gene and protein frames
Mapped synthesis describes AEDL effects in human bronchial epithelial cell culture on renewal markers (Ki67, Mcl-1, p53, CD79, NOS-3) and differentiation / mucin genes (Nkx2.1, SCGB1A1, SCGB3A2, FoxA1, FoxA2, MUC4, MUC5AC, SftpA1). A Russian full-text title frames tetrapeptide use against chronic bronchitis molecular mechanisms.
PubMed titles on peptide therapy in obstructive lung pathology and bronchial epithelium morphofunctional state sit in the same neighbourhood. Archive map of experimental systems only.
A PubMed title reports AEDL effects on DNA thermostability. Separate work maps short exogenous peptides on CLE, KNOX1 and GRF family genes in Nicotiana tabacum, and a CyberLeninka PDF covers Ala-Glu-Asp-Leu protection of tobacco sprouts and callus under salinity.
PubMed also indexes organotypic tissue-culture titles on tissue-specific peptide effects in young and old rats, and differentiation during ageing. These sit beside the bronchial series.
The corpus lives in the St. Petersburg Institute of Bioregulation and Gerontology short-peptide programme and closely adjacent Russian laboratories. Bronchial epithelium gene work and obstructive-lung models are densest there; plant and organotypic titles widen the map.
Russian clinical-series language on chronic bronchitis appears in school reviews. This page treats that as archive texture, not a rating.
Open limits
How much of the gene-regulation texture is single-school density versus multi-lab convergence?
Which PubMed titles extend bronchial protocols, and which are broader short-peptide adjacency?
Plant callus and DNA thermostability findings sit outside human lung models and are not treated as clinical bridges here.
Russian full-text papers
Open-access Russian academic PDFs on CyberLeninka where we have them.
lekarstvennye peptidnye preparaty proshloe nastoyaschee buduscheeRussian full text
perspektivy primeneniya tetrapeptida v lechenii hronicheskogo bronhita mRussian full text
rol peptidnyh bioregulyatorov v povyshenii effektivnosti lecheniya bolnyRussian full text
alveolyarnye makrofagi i surfaktant legkih pri disbalanse dofaminergicheRussian full text
zaschitnoe deystvie peptida alagluaspleu na prorostki i kallusnuyu kultuRussian full text
5 in corpus · off-topic retrieval rows removed (SIADH, neuromidin, cystic fibrosis carbohydrate, hyperprolactinemia, paraneoplastic)
Also on PubMed
2017[ANTIINFLAMMATORY AND REGENERATIVE EFFECT OF PEPTIDE THERAPY IN THE MODEL OF OBSTRUCTIVE LUNG PATHOLOGY].PubMed
2015Modulating Effect of Peptide Therapy on the Morphofunctional State of Bronchial Epithelium in Rats with Obstructive Lung Pathology. doi:10.1007/s10517-015-3047-xPubMed
2011Effect of the peptide bronchogen (Ala-Asp-Glu-Leu) on DNA thermostability. doi:10.1007/s10517-011-1146-xPubMed
2006[The tissue-specific effect of synthetic peptides-biologic regulators in organotypic tissues culture in young and old rats].PubMed
2017Short Exogenous Peptides Regulate Expression of CLE, KNOX1, and GRF Family Genes in Nicotiana tabacum. doi:10.1134/S0006297917040149PubMed
2012Peptides tissue-specifically stimulate cell differentiation during their aging. doi:10.1007/s10517-012-1664-1PubMed
6 curated
Still open
Does the epithelial gene set mapped in culture show up in later in vivo lung models in the same school?
How should the plant callus salinity series be read beside bronchial epithelium work?
Is telomerase language in the 2020 master review direct for AEDL, or borrowed from the wider tetrapeptide family?
How dense is independent replication outside the originating circle?
Reviewed against the archive corpora on 2026-09-19. Source-grounded. No clinical claims. Archive / history / research only. No medical advice. No dosing, synthesis, sourcing, or health claims.